Abstract
PROINSULIN has little or no biological activity1, but is present in the circulation2 and produces insulin-like effects when injected into normal animals3,4 and alloxan diabetic rats5. It has no effect, however, when injected into eviscerated, hepatectomized rats4.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Steiner, D. F., Hallund, O., Rubenstein, A. H., Cho, S., and Bayliss, C., Diabetes, 17, 725 (1968).
Rubenstein, A. H., Cho, S., and Steiner, D. F., Lancet, i, 1353 (1968).
Schlichtkrull, J., Diabetologia, 4, 245 (1968).
Willms, B., Appels, A., Soling, H. D., and Creutzfeldt, W., Horm. Metab. Res., 1, 199 (1969).
Rubenstein, A. H., Melani, F., Pilkis, S., and Steiner, D. F., Postgrad. Med. J., 45, Suppl. 476 (1969).
Shaw, W. N., and Chance, R. E., Diabetes, 17, 737 (1968).
Morgan, C. R., and Lazarow, A., Diabetes, 12, 115 (1963).
Edelman, P. M., and Schwartz, I. L., Amer. J. Med., 40, 695 (1966).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
MASHITER, K., KING, T. Changes of Immunoreactivity of Proinsulin induced by Rat Tissue Extracts. Nature 224, 696–697 (1969). https://doi.org/10.1038/224696a0
Received:
Issue Date:
DOI: https://doi.org/10.1038/224696a0
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.