Abstract
RECENT work in which clones derived from single haemopoietic cells repopulate the erythroid, myeloid and lymphoid tissues of lethally irradiated mice suggests a common or single stem cell concept for the cells of the haemopoietic system1–3. In man, however, studies of the distribution of the Philadelphia (Ph) chromosome marker of chronic myelogenous leukaemia suggest a common stem cell for erythrocytes and granulocytes and a different stem cell for lymphocytes; this follows from the fact that the Ph chromosome is found in erythrocytic and granulocytic precursors but not in circulating lymphocytes4. We have examined the inter-relationships of the blood cells in normal human subjects, utilizing the mosaicism resulting from X chromosome inactivation ; specifically, we are asking whether erythrocytes (E), granulocytes (G) and lymphocytes (L) arise from common or from different stem cells.
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GANDINI, E., GARTLER, S. Glucose-6-phosphate Dehydrogenase Mosaicism for studying the Development of Blood Cell Precursors. Nature 224, 599–600 (1969). https://doi.org/10.1038/224599a0
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DOI: https://doi.org/10.1038/224599a0
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