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Hyposensitivity of Smooth Muscle to Noradrenaline caused by Sympathetic Hyperinnervation

Nature volume 224, pages 385–386 (1969)Cite this article

Abstract

MUCH research has been carried out on the effects of nerve growth factor (NGF)1–3, a polypeptide substance4,5 which enhances the proliferation and ripening of neuroblasts in spinal and sympathetic neurons6,7. After injection of NGF into a newborn animal, a considerable increase occurs in the number and size of nerve cell bodies in sympathetic ganglia6,7 as well as the number of centrifugal sympathetic axons and the density of endings in numerous effector organs6,8,9.

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Authors and Affiliations

  1. Department of Animal Physiology, Lomonossov Moscow State University,

    N. A. KUZMICHEVA, A. S. ORLOVA & I. M. RODIONOV

  2. Institute of Biological and Medical Chemistry,

    V. M. RODIONOV

  3. Laboratory of Biogenic Amines, First Medical Institute,

    T. D. BOLSHAKOVA, T. A. LUKICHEVA, V. V. MENSHIKOV & E. P. FROLOV

  4. Department of Histology, Second Medical Institute, Moscow

    V. N. YARYGIN

Authors
  1. N. A. KUZMICHEVA
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  2. A. S. ORLOVA
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  3. I. M. RODIONOV
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  4. V. M. RODIONOV
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  5. T. D. BOLSHAKOVA
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  6. T. A. LUKICHEVA
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  7. V. V. MENSHIKOV
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  8. E. P. FROLOV
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  9. V. N. YARYGIN
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KUZMICHEVA, N., ORLOVA, A., RODIONOV, I. et al. Hyposensitivity of Smooth Muscle to Noradrenaline caused by Sympathetic Hyperinnervation. Nature 224, 385–386 (1969). https://doi.org/10.1038/224385a0

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  • DOI: https://doi.org/10.1038/224385a0

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