Abstract
CELLS infected with polyoma virus may undergo a cytocidal interaction or a moderate one in which a fraction of the population is transformed. In either case a new complement fixing antigen1, known as T-antigen2, appears in the nucleus of the infected cells and cellular DNA synthesis is stimulated3–6. A requirement for DNA stimulation is that cells are not actively dividing7. It has been suggested that a correlation exists between appearance of T-antigen and stimulation of host DNA synthesis1. The use of cells which are incapable of synthesizing DNA would facilitate study of this relationship because in the available systems mitotic activity and DNA synthesis of contact-inhibited cells are only temporarily and partially repressed. The experiments reported here show that polyoma virus induces an abortive infection in peritoneal macrophages, a system in a steady state situation8, and that synthesis of T-antigen and DNA appears as two unrelated processes.
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MALLUCCI, L. T-Antigen and DNA Synthesis in Macrophages infected with Polyoma Virus. Nature 223, 630–632 (1969). https://doi.org/10.1038/223630a0
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DOI: https://doi.org/10.1038/223630a0
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