Abstract
ACETYLCHOLINE (ACh) is an important biological transmitter, and in the presence of cholinesterase (ChE) it undergoes hydrolysis. We have studied this hydrolysis using quantum chemical methods.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Wilson, I. B., Ann. NY Acad. Sci., 144, 664 (1967).
Wilson, I. B., Bergman, F., and Nachmanson, D., J. Biol. Chem., 186, 781 (1950).
Wilson, I. B., and Bergman, F., J. Biol. Chem., 186, 683 (1950).
Gutfreund, H., and Sturtevant, J. M., Biochem. J., 63, 656 (1956).
Schaffer, N. K., May, S. C., and Summeron, W. H., J. Biol. Chem., 202, 67 (1953).
Wilson, I. B., and Harrison, M. A., J. Biol. Chem., 236, 2292 (1961).
Khromov-Borisov, N. V., and Michelson, M. J., Pharm. Rev., 18 1051.
Hoffmann, R., and Lipscomb, G., J. Chem. Phys., 36, 2179 (1962).
Kagan, G. M., and Fundiler, I. N., Teoret i Exp. Him., 3, 444 (1967).
Kosower, E. M., Molecular Biochemistry, 128 (McGraw-Hill, New York, 1962).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
FARKAS, M., KRUGLYAK, J. Hydrolysis of Acetylcholine studied by a Quantum Chemical Method. Nature 223, 523–524 (1969). https://doi.org/10.1038/223523a0
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1038/223523a0
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.