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Caffeine and Nicotine penetrate the Pre-implantation Blastocyst

Nature volume 223, pages 410–411 (1969)Cite this article

Abstract

CAFFEINE and nicotine are examples of compounds from our chemical environment to which we are widely and constantly exposed and for which there are some indications of toxic effects on various aspects of reproduction. Caffeine effects chromosomal breakages in both plants and animals1, and an increased incidence of congenital malformations in the offspring of mice treated with this compound has been observed2. Caffeine also possesses mutagenic properties, although it has been estimated that this risk for humans is small3.

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Authors and Affiliations

  1. Department of Pharmacology, The George Washington University, School of Medicine, Washington, DC, 2005

    S. FABRO & S. M. SIEBER

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  1. S. FABRO
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  2. S. M. SIEBER
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FABRO, S., SIEBER, S. Caffeine and Nicotine penetrate the Pre-implantation Blastocyst. Nature 223, 410–411 (1969). https://doi.org/10.1038/223410a0

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