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Androgenic Induction of α2u-Globulin in the Rat: Requirement of an Intact Pituitary

Nature volume 223, pages 399–400 (1969)Cite this article

Abstract

A SEX dependent urinary protein in the rat has been described by Roy and Neuhaus1–4. This protein is an α2-globulin (α2U) of hepatic origin and has a molecular weight of 26,400 (refs. 2 and 3). It is rapidly excreted in the urine3. The level of α2U in blood is therefore very low (< 3 mg per 100 ml. blood)3. This protein is absent in females and immature male rats. The synthesis of α2U is very sensitive to hormonal manipulations4. Treatment with testosterone of the spayed females induces its synthesis whereas treatment of adult male rats with oestradiol brings about a complete repression4. A quantitative immunological method for the assay of α2U has been described3. All of these above mentioned properties make α2U a very convenient system for studying the possible hormonal control of gene action in the mammalian system. In this communication we report our studies on the requirement of the pituitary gland for the androgenic induction of α2U in spayed rats.

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References

  1. Roy, A. K., and Neuhaus, O. W., Proc. Soc. Exp. Biol. and Med., 121, 894 (1966).

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Authors and Affiliations

  1. Department of Biochemistry, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, 15213

    MAHENDRA KUMAR, ARUN K. ROY & A. E. AXELROD

Authors
  1. MAHENDRA KUMAR
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  2. ARUN K. ROY
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  3. A. E. AXELROD
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KUMAR, M., ROY, A. & AXELROD, A. Androgenic Induction of α2u-Globulin in the Rat: Requirement of an Intact Pituitary. Nature 223, 399–400 (1969). https://doi.org/10.1038/223399a0

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