Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Allotypic Marker GPγ2-I of Guinea-pig Immunoglobulins

Nature volume 223, pages 398–399 (1969)Cite this article

Abstract

EXTENSIVE use of the guinea-pig as an experimental animal necessitated investigation of its immunoglobulins. The guinea-pig has been found to possess two IgG classes: γ1 and γ2 differing in many characteristics, in particular in their immunoelectrophoretic mobility1,2. The antibodies of γ1 class mediate passive systemic or cutaneous anaphylaxis; γ2 antibodies cannot do this, but they inhibit specifically passive cutaneous anaphylaxis provoked by γ1 antibodies by competing for the antigen. The antibodies of γ2 class lack the receptors for fixation to guinea-pig tissues and do not compete with sensitizing antibodies for the receptor sites3. The γ2 antibodies fix complement in the presence of antigen; γ1 antibodies lack this capability. The antibodies of γ2 class are more efficient than γ1 in provoking haemorrhagic necrosis in reverse passive Arthus reaction4. This topic has recently been reviewed in detail5.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Benacerraf, B., Ovary, Z., Bloch, K. J., and Franklin, E. C., J. Exp. Med., 117, 937 (1963).

    Article  CAS  Google Scholar 

  2. White, R. G., Jenkins, G. C., and Wilkinson, P. C., Intern. Arch. Allergy, 22, 156 (1963).

    Article  CAS  Google Scholar 

  3. Ovary, Z., Benacerraf, B., and Bloch, K. J., J. Exp. Med., 117, 951 (1963).

    Article  CAS  Google Scholar 

  4. Bloch, K. J., Kourilsky, F. M., Ovary, Z., and Benacerraf, B., J. Exp. Med., 117, 965 (1963).

    Article  CAS  Google Scholar 

  5. Bloch, K. J., Prog. Allergy, 10, 84 (1967).

    PubMed  Google Scholar 

  6. Natvig, J. B., and Kunkel, H. G., in Serum Groups, Series Haematologica, 1, 66 (Munksgaard, Copenhagen, 1968).

    Google Scholar 

  7. Kelus, A. S., and Gell, P. G. H., Prog. Allergy, 11, 141 (1967).

    CAS  PubMed  Google Scholar 

  8. Oudin, J., Proc. Roy. Soc., B, 166, 207 (1966).

    ADS  CAS  Google Scholar 

  9. Herzenberg, L. A., McDevitt, H. O., and Herzenberg, L. A., Ann. Rev. Genetics, 2, 209 (1968).

    Article  CAS  Google Scholar 

  10. Benacerraf, B., and Gell, P. G. H., Nature, 189, 586 (1961).

    Article  ADS  Google Scholar 

Download references

Author information

Author notes

  1. A. S. KELUS

    Present address: Basel Institute for Immunology, PO Box CH-4002, Basel, Switzerland

Authors and Affiliations

  1. Department of Experimental Pathology, University of Birmingham,

    A. S. KELUS

Authors
  1. A. S. KELUS
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

KELUS, A. Allotypic Marker GPγ2-I of Guinea-pig Immunoglobulins. Nature 223, 398–399 (1969). https://doi.org/10.1038/223398a0

Download citation

  • Received:

  • Revised:

  • Issue Date:

  • DOI: https://doi.org/10.1038/223398a0

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing