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Radiation-induced Depression of Primary and Secondary Antibody Responses to Bacteriophage φX 174 in vitro

Nature volume 223, pages 306–308 (1969)Cite this article

Abstract

WHOLE body X-irradiation depresses or enhances the antibody response depending on the dosage and its temporal relationship to injection of antigen in the animal1. Using organ cultures of rabbit lymph nodes, we succeeded in initiating both primary and secondary types of antibody response to bacteriophage φX 174 in vitro2,3. The experiments reported here (a) test this in vitro system for its use in the study of radiation effects on the antibody response, (b) further elucidate the mechanisms of radiation-induced enhancement of the primary antibody response, and (c) compare radiosensitivity of primary and secondary responses initiated in the cultures.

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References

  1. Taliaferro, W. H., Taliaferro, L. G., and Jaroslow, B. N., Radiation and Immune Mechanisms (Academic Press, NY, and London, 1964).

    Google Scholar 

  2. Tao, T. W., and Uhr, J. W., Science, 151, 1096 (1966).

    Article  ADS  CAS  Google Scholar 

  3. Tao, T. W., J. Immunol., 101, 1253 (1968).

    PubMed  CAS  Google Scholar 

  4. Tao, T. W., and Hertig, A. T., Amer. J. Anat., 116, 315 (1965).

    Article  CAS  Google Scholar 

  5. Adams, M. H., Bacteriophages (Interscience Publishers, Inc., NY, 1959).

    Google Scholar 

  6. Pribnow, J. G., and Silverman, M. S., J. Immunol., 98, 225 (1967).

    PubMed  CAS  Google Scholar 

  7. Taliaferro, W. H., and Jaroslow, B. N., J. Infect. Dis., 107, 341 (1960).

    Article  CAS  Google Scholar 

  8. Dixon, F. J., and McConahey, P. J., J. Exp. Med., 117, 833 (1963).

    Article  CAS  Google Scholar 

  9. Makinodan, T., Kastenbaum, M. A., and Peterson, W. J., J. Immunol., 88, 31 (1962).

    CAS  Google Scholar 

  10. Stecher, V. J., and Thorbecke, G. J., J. Exp. Med., 125, 33 (1967).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Pathology, Harvard Medical School, Boston, Massachusetts, 02115

    TIEN-WEN TAO & PATRICIA L. LEARY

Authors
  1. TIEN-WEN TAO
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  2. PATRICIA L. LEARY
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TAO, TW., LEARY, P. Radiation-induced Depression of Primary and Secondary Antibody Responses to Bacteriophage φX 174 in vitro. Nature 223, 306–308 (1969). https://doi.org/10.1038/223306a0

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  • DOI: https://doi.org/10.1038/223306a0

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