Abstract
THE structure and interactions of actinomycin D (ACD) have recently been much studied (refs. 1, 2 and Fig. 1). We have made an extensive nuclear magnetic resonance study of ACD and in this communication we report the assignment and the effects of solvent and temperature on the N—H, NH2 and actinocin ring proton signals.
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References
Ziffer, H., Yamaoka, K., and Mauger, A. B., Biochemistry, 7, 996 (1968); Yamaoka, K., and Ziffer, H., ibid., 7, 1001 (1968); Crothers, D. M., Sabol, S. L., Ratner, D. I., and Müller, W., ibid., 7, 1817 (1968). Courtois, Y., Guschlbauer, W., and Fromageot, P., Europ. J. Biochem., 6, 106 (1968). Müller, W., and Spatz, H., Z. Naturforschg., 20b, 842 (1965); Müller, W., and Emme, I., ibid., 20b, 835 (1965). Pullman, B., Biochim. Biophys. Acta, 88, 440 (1964); Behme, M. T. A., and Cordes, E. H., ibid., 108, 312 (1965).
Reich, E., and Goldberg, I. H., Prog. Nucleic Acid Research and Mol. Biol. (edit. by Davidson, J. N., and Conn, W. E.), 1, 183 (Academic Press, New York, 1968); also references to earlier work cited therein.
Karplus, M., J. Chem. Phys., 30, 11 (1959).
Bystrov, V. F., Portnova, S. L., Tsetlen, V. I., Ivanov, V. T., and Ovchinnikov, Yu. A., Tetrahedron, 25, 493 (1969).
Lesch, S. J., Nemethy, G., and Scheraga, H. A., Biopolymers, 4, 369 (1966).
Kakshiminarayanan, A. V., Sasisekharan, V., and Ramachandran, G. N., Conformation of Biopolymers (edit. by Ramachandran, G. N.), 1, 61 (Academic Press, New York, 1967).
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VICTOR, T., HRUSKA, F., HIKICHI, K. et al. Nuclear Magnetic Resonance Study of the Structure and Interactions of Actinomycin D: Temperature and Solvent Effects on the N—H and NH2 Groups . Nature 223, 302–303 (1969). https://doi.org/10.1038/223302a0
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DOI: https://doi.org/10.1038/223302a0
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