Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Synthesis of Small Nuclear Ribonucleic Acids of Mammalian Cells in relation to the Cell Cycle

Nature volume 223, pages 1063–1064 (1969)Cite this article

Abstract

SEVERAL distinct species of low molecular weight RNA from nuclei and nucleoli of mammalian cells1–6 can be resolved by polyacrylamide gel electrophoresis. Labelling studies with HeLa cells7 show that the low molecular weight RNA is metabolically stable and partitioned between nucleolus and nucleoplasm. We report here the timing of its synthesis in synchronized cell cultures.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Muramatsu, M., Hodnett, J., and Busch, H., J. Biol. Chem., 241, 1544 (1966).

    CAS  PubMed  Google Scholar 

  2. Nakamura, T., Prestayko, A. W., and Busch, H., J. Biol. Chem., 243, 1368 (1968).

    CAS  PubMed  Google Scholar 

  3. Dingham, C. W., and Peacock, A. C., Biochemistry, 6, 1818 (1967).

    Article  Google Scholar 

  4. Dingham, C. W., and Peacock, A. C., Biochemistry, 7, 659 (1968).

    Article  Google Scholar 

  5. Prestayko, A. W., and Busch, H., Biochim. Biophys. Acta, 169, 327 (1968).

    Article  CAS  Google Scholar 

  6. Burdon, R. H., and Clason, A. E., J. Mol. Biol., 39, 113 (1969).

    Article  CAS  Google Scholar 

  7. Weinberg, R. A., and Penman, S., J. Mol. Biol., 38, 289 (1968).

    Article  CAS  Google Scholar 

  8. Burdon, R. H., and Adams, R. L. P. A., Biochim. Biophys. Acta, 174, 322 (1969).

    Article  CAS  Google Scholar 

  9. Robbins, E., and Scharff, M., in Cell Synchrony (edit. by Cameron, I. L., and Padilla, G. M.), 353 (Academic Press, New York, 1966).

    Book  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Biochemistry, University of Glasgow,

    A. E. CLASON & R. H. BURDON

Authors
  1. A. E. CLASON
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. R. H. BURDON
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

CLASON, A., BURDON, R. Synthesis of Small Nuclear Ribonucleic Acids of Mammalian Cells in relation to the Cell Cycle. Nature 223, 1063–1064 (1969). https://doi.org/10.1038/2231063a0

Download citation

  • Received:

  • Revised:

  • Issue Date:

  • DOI: https://doi.org/10.1038/2231063a0

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing