Abstract
MOST red cell cold agglutinins encountered in clinical practice show anti-I specificity, reacting best with I red cells and weakly or not at all with i (adult) or cord (icord) cells1,2. Because red cells from adults of i status are not generally available, a convenient and commonly used way of determining cold agglutinin specificity is to compare titres obtained with OI and Oicord cells. Here I describe a remarkable heterogeneity in the reactions of anti-I sera and of cord cells from different donors. Such heterogeneity was a feature even of cold agglutinins associated with a single aetiological agent, infection with Mycoplasma pneumoniae.
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FEIZI, T. Antibody Heterogeneity of Anti-I Cold Agglutinins as shown by Cord Cell Studies. Nature 222, 1288–1289 (1969). https://doi.org/10.1038/2221288a0
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DOI: https://doi.org/10.1038/2221288a0
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