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Mammary Gland Neoplasms after Fission Neutron Irradiation

Abstract

A SINGLE sublethal whole body X-ray exposure of young female Sprague–Dawley rats results in the early appearance of mammary neoplasms1, the incidence of which seems to be linearly related to dose between 25 r. and 400 r. (ref. 2). Earlier comparative studies on the incidence of mammary neoplasms after irradiation with fission neutrons and 60Co γ-rays3 revealed that the incidence of neoplasms was significantly higher, and the life span considerably shorter, in rats irradiated with neutrons.

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References

  1. Shellabarger, C. J., Cronkite, E. P., Bond, V. P., and Lippincott, S. W., Radiat. Res., 6, 501 (1957).

    Article  ADS  CAS  Google Scholar 

  2. Bond, V. P., Cronkite, E. P., Lippincott, S. W., and Shellabarger, C. J., Radiat. Res., 12, 276 (1960).

    Article  ADS  CAS  Google Scholar 

  3. Vogel, jun., H. H., and Jordan, D. L., Radiation Effects in Physics, Chemistry and Biology (edit. by Ebert and Howard, A.). Proc. Second Intern. Cong. on Radiat. Res., Harrogate, England, 1962. Loutit, J. T., Rapporteur, Carcinogenesis, 373 (North Holland, Amsterdam, 1963).

    Google Scholar 

  4. Vogel, jun., H. H., Blomgren, R. A., and Bohlin, N. J. G., Nucleonics, 11, 28 (1953).

    CAS  Google Scholar 

  5. Clark, J. W., Jordan, D. L., and Vogel, jun., H. H., Amer. J. Roentgenol. Radium Therap. Nuclear Med., 77, 524 (1957).

    CAS  Google Scholar 

  6. Rambach, W. A., Cooper, J. A. D., Alt, H. L., Vogel, jun., H. H., Clark, J. W., and Jordan, D. L., Radiat. Res., 10, 148 (1959).

    Article  ADS  CAS  Google Scholar 

  7. Shellabarger, C. J., and Schmidt, R. W., Radiat. Res., 30, 497 (1967).

    Article  ADS  CAS  Google Scholar 

  8. Shellabarger, C. J., Bond, V. P., Aponte, G. E., and Cronkite, E. P., Cancer Res., 26, 509 (1966).

    CAS  PubMed  Google Scholar 

  9. Hartung, Q. L., Kent, S. P., and Sproul, jun., J. A., Cancer Res., 18, 736 (1958).

    Google Scholar 

  10. Thompson, S. W., Huseby, R. A., Fox, M. A., Davis, C. L., and Hunt, R. D., J. Nat. Cancer Inst., 27, 1031 (1961).

    Google Scholar 

  11. Tannenbaum, A., Vesselinovitch, S. D., Maltoni, C., and Mitchell, D. S., Cancer Res., 22, 1362 (1962).

    CAS  PubMed  Google Scholar 

  12. Davis, R. K., Stevenson, G. T., and Bush, K. A., Cancer Res., 16, 194 (1956).

    CAS  PubMed  Google Scholar 

  13. Code of Federal Regulation, USAEC, Title 10, Part 20; Standards for Protection against Radiation, p. 64 (1968).

  14. Radiation Quantities and Units, US Nat. Bur. Standards Handbook, 84 (1962) (ICRU Report 10a).

  15. Conger, A. D., Randolph, M. L., Sheppard, C. W., and Luippold, H. F., Radiat. Res., 9, 525 (1958).

    Article  ADS  CAS  Google Scholar 

  16. Randolph, M. L., Ann. NY Acad. Sci., 114, 85 (1964).

    Article  ADS  CAS  Google Scholar 

  17. Thoday, J. M., and Read, J., Nature, 163, 133 (1949).

    Article  ADS  CAS  Google Scholar 

  18. Evans, H. J., Neary, G. J., and Williamson, F. S., Intern. J. Rad. Biol., 1, 216 (1959).

    CAS  Google Scholar 

  19. Russell, W. L., Radiation Biology, 1 (edit. by Hollaender, A.), chap. 12, 825 (McGraw-Hill, New York, 1954).

    Google Scholar 

  20. Neary, G. J., Munson, R. J., and Mole, R. H., Chronic Radiation Hazards (Pergamon Press, 1957).

    Google Scholar 

  21. Bateman, J. L., Bond, V. P., and Rossi, H. H., in Symp. Biological Effects of Neutrons, 2, 321 (International AEA, Vienna, 1964).

    Google Scholar 

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VOGEL, H. Mammary Gland Neoplasms after Fission Neutron Irradiation. Nature 222, 1279–1281 (1969). https://doi.org/10.1038/2221279a0

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