Abstract
Two early events in the initiation of lymphocyte growth by phytohaemagglutinin (PHA) are the acceleration of phosphatidylinositol (PI) turnover1 and the agglutination of the lymphocytes2. To determine whether these two responses are related, a specific inhibitor of the lymphocyte agglutination, N-acetyl-D-galactosamine (NAGA)2, was tested for its effect on the PI response. NAGA was found greatly to inhibit the acceleration of PI turnover by PHA, which suggests that the abilities of PHA to agglutinate lymphocytes and to activate PI metabolism are related properties of this mitogen.
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References
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FISHER, D., MUELLER, G. N-Acetyl-D-galactosamine inhibits the Early Phospholipid Response by Lymphocytes to Phytohaemagglutinin. Nature 221, 566–567 (1969). https://doi.org/10.1038/221566a0
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DOI: https://doi.org/10.1038/221566a0
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