Abstract
In β-thalassaemia translation of haemoglobin β-chain mRNA appears to be normal. This suggests that defective regulation of mRNA production is probably responsible for the reduced rate of β-chain synthesis in this disorder.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Weatherall, D. J., Clegg, J. B., and Naughton, M. A., Nature, 208, 1061 (1965).
Clegg, J. B., and Weatherall, D. J., Nature, 215, 1241 (1967).
Heywood, D., Karon, M., and Weissman, S., J. Lab. Clin. Med., 66, 476 (1965).
Bank, A., and Marks, P. A., Nature, 212, 1198 (1966).
Huehns, E. R., and Modell, C. B., Trans. Roy. Soc. Trop. Med. Hyg., 61, 157 (1967).
Bargellesi, A., Pontremoli, S., Menini, C., and Conconi, F., Europ. J. Biochem., 3, 364 (1968).
Dintzis, H. M., Proc. US Nat. Acad. Sci., 47, 247 (1961).
Lingrel, J. B., and Borsook, H., Biochemistry, 2, 309 (1963).
Allen, D. W., Schroeder, W. A., and Balog, J., J. Amer. Chem. Soc., 80, 1628 (1958).
Clegg, J. B., Naughton, M. A., and Weatherall, D. J., J. Mol. Biol., 19, 91 (1966).
Bray, G. A., Anal. Biochem., 1, 279 (1960).
Nathan, D. G., and Gunn, R. B., Amer. J. Med., 41, 815 (1966).
Rieder, R. F., and Weatherall, D. J., J. Clin. Invest., 44, 42 (1965).
Winslow, R. M., and Ingram, V. M., J. Biol. Chem., 241, 1144 (1966).
Kazazian, H. M., and Itano, H. A., J. Biol. Chem., 243, 2048 (1968).
Baglioni, C., and Campana, T., Europ. J. Biochem., 2, 480 (1967).
Weatherall, D. J., in Prog. in Med. Genetics (edit. by Steinberg, A., and Beam, A. G.), 5, 8 (1967).
Hunt, T., Hunter, T., and Munro, A., J. Mol. Biol. (in the press).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
CLEGG, J., WEATHERALL, D., NA-NAKORN, S. et al. Haemoglobin Synthesis in β-Thalassaemia. Nature 220, 664–668 (1968). https://doi.org/10.1038/220664a0
Received:
Issue Date:
DOI: https://doi.org/10.1038/220664a0
This article is cited by
-
Thalassaemia: the long road from bedside to genome
Nature Reviews Genetics (2004)
-
Why inclusion bodies do assume different locations in thalassaemic erythrocytes
Blut (1982)
-
Regulatory interactions involving two hemoglobin loci of Chironomus
Biochemical Genetics (1973)
-
Synthesis of Hb Lepore(α2δ β2): Influence of δ and β Nucleotide Sequence on Synthesis of δ β Chain
Nature New Biology (1972)
-
Haemoglobin Synthesis during Erythroid Maturation in β-Thalassaemia
Nature New Biology (1972)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
