Abstract
PATIENTS with Hunter–Hurler syndrome, which is an inborn error of metabolism, have excessive deposition of acid mucopolysaccharides (AMPS) in various organs1,2, and large amounts of chondroitin sulphate B and/or heparitin sulphate are produced in the urine3. In contrast, normal people excrete a small amount of AMPS, chiefly in the form of chondroitin sulphate C and chondroitin sulphate A. The determination of urinary AMPS is being used extensively in the study and in the diagnosis of this disease and of its several genetic variants.
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CONSTANTOPOULOS, G. Hunter–Hurler Syndrome : Gel Filtration and Dialysis of Urinary Acid Mucopolysaccharides. Nature 220, 583–585 (1968). https://doi.org/10.1038/220583b0
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DOI: https://doi.org/10.1038/220583b0
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