Abstract
IT has been shown repeatedly that tumours induced in mice and rats at the site of subcutaneous injection of polycyclic hydrocarbons such as methylcholanthrene possess antigens capable of eliciting transplantation resistance in isogenic and autochthonous hosts1–4. A remarkable antigenic individuality characterizes these tumours; immunization with any one tumour induces resistance to that tumour and usually to no other. Resistance to transplants can be transferred to normal recipients by means of viable cells from the spleen, lymph nodes or peritoneal cavity of actively immunized donors. The serum of immune animals is ineffective in conveying resistance and may induce enhanced growth of the tumour transplant5,6. Antibody to surface components of the tumour cell has been demonstrated in the serum of immunized animals by a variety of serological techniques5–9. It is not clear, however, whether the antigens being detected by these techniques are the specific transplantation antigens or are unrelated cellular antigens, such as the G (Gross) cellular antigen (associated with infection by Gross leukaemia virus) which occurs commonly in tumours induced by methylcholanthrene in mice10,11.
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OETTGEN, H., OLD, L., MCLEAN, E. et al. Delayed Hypersensitivity and Transplantation Immunity elicited by Soluble Antigens of Chemically Induced Tumours in Inbred Guinea-pigs. Nature 220, 295–297 (1968). https://doi.org/10.1038/220295a0
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DOI: https://doi.org/10.1038/220295a0
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