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Protection against Whole Body X-irradiation by Adrenochrome Monoguanylhydrazone Methanesulphonate in Mice

Abstract

INTENSIVE studies of radioprotective chemicals have recently been reviewed1,2. Unfortunately, however, no agent with a definite protective effect which is sufficiently non-toxic to be clinically applicable has been discovered yet. We have been carrying out some experimental investigations of radiation protection by agents with low toxicity3, and describe here experiments involving an adrenochrome derivative.

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References

  1. Thomson, J. F., Radiation Protection in Mammals (Reinhold Publishing Corp., London, 1962).

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  2. Bacq, Z. M., Chemical Protection against Ionizing Radiation (Thomas, Springfield, Illinois, 1965).

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  3. Sugahara, T., Nagata, H., and Tanaka, T., Radiat. Res., 29, 516 (1966); Nagata, H., Nishida, H., Sugahara, T., and Tanaka, T., Nippon Acta Radiol., 26, 975 (1966).

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  4. Higuchi, S., Fukakusa, S., and Tada, K., Nippon Acta Radiol., 32, 1229 (1957).

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SUGAHARA, T., TANAKA, T. Protection against Whole Body X-irradiation by Adrenochrome Monoguanylhydrazone Methanesulphonate in Mice. Nature 220, 271–272 (1968). https://doi.org/10.1038/220271a0

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  • DOI: https://doi.org/10.1038/220271a0

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