Abstract
ONE X chromosome of the human female lymphocyte has been shown to synthesize DNA later than do its homologue and other chromosomes of the complement1–3. Attempts by us to demonstrate a similar replication pattern for chromosomal protein have been unsuccessful4. In this study, cultures were exposed to 1 µCi/ml. only of 3H-arginine or 3H-lysine for the 4–6 h previous to chromosome preparation. It was found, however, if 5 µCi/ml. of 3H-arginine were used, a large chromosome of the 6-X-12 group seemed to be synthesizing protein later than was the rest of the complement (Fig. 1).
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CHERNICK, B. Late Synthesis of Protein on the Presumptive X Chromosome of the Human Female Lymphocyte. Nature 220, 195–196 (1968). https://doi.org/10.1038/220195a0
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DOI: https://doi.org/10.1038/220195a0
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