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HL-A Substances from Human Spleens

Abstract

TRANSPLANTATION of tissues between humans is usually accompanied by the appearance in the serum of recipients of cytotoxic antibodies which reflect differences at the HL-A genetic locus. Antigenic specificities which are determined by this locus are frequently characterized by means of soluble serological inhibitors, prepared either by autolytic or proteolytic digestion of cell membranes. (Correlation of HL-A specificities used by various groups of workers is given in ref. 1.)

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References

  1. Histocompatibility Testing (edit. by Curtoni, E. S., Mattiuz, P. L., and Tosi, R. M.), Appendix, Table II (Munksgaard, Copenhagen, 1968).

  2. Nathenson, S. G., and Davies, D. A. L., Proc. US Nat. Acad. Sci., 56, 476 (1966).

    Article  ADS  CAS  Google Scholar 

  3. Batchelor, J. R., and Chapman, B. A., Ann. NY Acad. Sci., 129, 529 (1966).

    Article  ADS  CAS  Google Scholar 

  4. Sanderson, A. R., Nature, 216, 23 (1967).

    Article  ADS  Google Scholar 

  5. Sanderson, A. R., and Batchelor, J. R., Nature, 219, 184 (1968).

    Article  ADS  CAS  Google Scholar 

  6. Bock, J., and Ling, N-S., Anal. Chem., 26, 1543 (1954).

    Article  CAS  Google Scholar 

  7. Pusztai, A., and Morgan, W. J. T., Nature, 182, 648 (1958).

    Article  ADS  CAS  Google Scholar 

  8. Pusztai, A., and Morgan, W. J. T., Biochem. J., 81, 639 (1961).

    Article  CAS  Google Scholar 

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SANDERSON, A. HL-A Substances from Human Spleens. Nature 220, 192–195 (1968). https://doi.org/10.1038/220192a0

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