Abstract
AN active chloride pump has been suggested as the chief driving force for the process of secretion by human sweat glands1. Such a mechanism has been used as an important premise in a hypothesis to describe the basic defect in cystic fibrosis2. Because the evidence for such a pump in the sweat gland is very weak we have reinvestigated this problem to find out whether our concept of a sodium pump3 should be revised, or whether some alternative mechanism should be suggested.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Emrich, H. M., and Ullrich, K. J., Pflügers Arch., 290, 298 (1966).
Johansen, P. G., Anderson, Ch. M., and Hadorn, B., Lancet, i, 455 (1968).
Slegers, J. F. G., in Control Mechanisms in Cystic Fibrosis (Ciba Foundation, London, 1968).
Forster, K. G., J. Physiol., 184, 106 (1966).
Slegers, J. F. G., thesis (Drukkerij Gebr. Janssen N.V., Nijmegen, 1966).
Gibbs, G. E., in Cystic Fibrosis, Physiology and Pathophysiology of Serous Secretion, Clinical Investigations and Therapy (edit. by Rossi, E., and Stoll, E.), (S. Karger, 1967).
Richterich, B., and Friolet, B., Metabolism, 12, 1112 (1963).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
SLEGERS, J., MOONS, W. Effect of Acetazolamide on the Chloride Shift and the Sodium Pump in Secretory Cells. Nature 220, 181–182 (1968). https://doi.org/10.1038/220181a0
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1038/220181a0
This article is cited by
-
Hyperosmotic secretion at low transport rates in the cat sweat gland
Pfl�gers Archiv European Journal of Physiology (1973)
-
The localization of sodium transport sites in a forward pumping secretory system
Pflügers Archiv (1971)
-
The cochlear potentials
Pfl�gers Archiv European Journal of Physiology (1970)
-
The additive effect of acetazolamide and ouabain on pancreatic secretion in vitro
Pfl�gers Archiv European Journal of Physiology (1969)
-
Enzyme secretion by the isolated rabbit pancreas: Absence of a relation with the Na?K activated ATPase
Pfl�gers Archiv European Journal of Physiology (1969)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
