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Conversion of Cyclamate to Cyclohexylamine in Rats

Nature volume 220, pages 178–179 (1968)Cite this article

Abstract

ALTHOUGH cyclamate is excreted largely unchanged in both laboratory animals and man1,2, recent reports have shown that cyclohexylamine can be a metabolite of cyclamate in some humans3,4. Kojima and Ichibagase3 reported the recovery in the urine of a human volunteer of an amount of cyclohexylamine which was equivalent to approximately 0.7 per cent of an orally administered dose of sodium cyclamate. Leahy, Wakefield and Taylor4 analysed the urine of five male laboratory workers for 5 days after each had been given a single dose of 3 g sodium cyclamate. One of the five subjects was found to excrete 0.8 per cent of the dose of cyclamate which was administered as cyclohexylamine; most of the dose was excreted as free cyclamate.

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References

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Authors and Affiliations

  1. Food and Drug Research Laboratories, Inc., Maspeth, New York

    B. L. OSER, S. CARSON & E. E. VOGIN

  2. Abbott Laboratories, North Chicago, Illinois

    R. C. SONDERS

Authors
  1. B. L. OSER
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  2. S. CARSON
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  3. E. E. VOGIN
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  4. R. C. SONDERS
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OSER, B., CARSON, S., VOGIN, E. et al. Conversion of Cyclamate to Cyclohexylamine in Rats. Nature 220, 178–179 (1968). https://doi.org/10.1038/220178a0

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