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Block of “Memory Transfer” by Actinomycin D

Abstract

THE mechanism of the effect of injection of brain extracts from trained animals into untrained ones is unknown. We recently suggested that the change of the behaviour of the recipient animal which follows the injection of the extract of a trained brain is probably caused by the derepressor effect of some material present in the extract on DNA of the neurones1. In the second step, newly formed mRNA induces the production of specific protein which is probably necessary for the formation of a stable memory trace. We describe here the effect of the combined application of brain extracts from trained animals with actmomycin D.

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REINIŠ, S. Block of “Memory Transfer” by Actinomycin D. Nature 220, 177–178 (1968). https://doi.org/10.1038/220177a0

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  • DOI: https://doi.org/10.1038/220177a0

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