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Allosteric Transitions of Glutamate Dehydrogenase

Abstract

L-GLUTAMATE dehydrogenase from beef liver, GDH (EC 1.4.1.3), has a molecular weight of 310,000 (referred to as the oligomer) consisting of six identical subunits1 and six active sites2.

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References

  1. Appella, E., and Tomkins, G. M., J. Mol. Biol., 18, 77 (1966).

    Article  CAS  Google Scholar 

  2. Bayley, P. M., and Radda, G. K., Biochem. J., 98, 105 (1966).

    Article  CAS  Google Scholar 

  3. Wolff, J., J. Biol. Chem., 237, 236 (1962).

    CAS  PubMed  Google Scholar 

  4. Frieden, C., Biochim. Biophys. Acta, 59, 484 (1962).

    Article  CAS  Google Scholar 

  5. Colman, R. F., and Frieden, C., J. Biol. Chem., 241, 3652, 3661 (1966).

    CAS  PubMed  Google Scholar 

  6. Dodd, G. H., and Radda, G. K., Biochem. Biophys. Res. Commun., 27, 500 (1967).

    Article  CAS  Google Scholar 

  7. Baker, B. R., Lee, W. W., and Tong, E., J. Theoret. Biol., 3, 459 (1962).

    Article  CAS  Google Scholar 

  8. Koshland, jun., D. E., and Némethy, G., and Filmer, D., Biochemistry, 5, 365 (1966).

    Article  Google Scholar 

  9. Kirtley, M. E., and Koshland, jun., D. E., J. Biol. Chem., 242, 4192 (1967).

    CAS  PubMed  Google Scholar 

  10. Dodd, G. H., and Radda, G. K., Biochem. J., 108, 5P (1968).

    CAS  Google Scholar 

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MALCOLM, A., RADDA, G. Allosteric Transitions of Glutamate Dehydrogenase. Nature 219, 947–949 (1968). https://doi.org/10.1038/219947a0

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  • DOI: https://doi.org/10.1038/219947a0

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