Abstract
THIS study is a test of a prediction that phleomycin1 attaches to the carbonyl oxygen of 2′-thymidine in DNA2. In non-living conditions, phleomycin and Hg++ do react with this site3; pretreatment of fibres with either HgCl2 or phleomycin prevents the other from reacting. Both phleomycin and HgCl2 inhibit growth. If they do compete for the same site in vivo, then the sum of the consequences of both taken separately should give a value greater than the inhibition exerted by the two reacted together but sequentially.
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PIETSCH, P., CORBETT, C. Competitive Effects of Phleomycin and Mercuric Chloride in vivo. Nature 219, 933–934 (1968). https://doi.org/10.1038/219933a0
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DOI: https://doi.org/10.1038/219933a0
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