Abstract
THE mechanism of the delayed necrosis that follows irradiation of nervous tissue is still little understood1. Adult nervous tissue is insensitive to X-irradiation compared with other tissues2. Hopewell and Wright3 showed that the capacity of cells in the rat cerebral cortex to react to injury caused by freezing was impaired if the brain had previously been locally irradiated. It was not clear which cells were involved, for in such an injury not only astrocytes, but probably microglia, mesodermal and meningeal elements as well as capillary endothelial cells would also take part in the response. A similar post-irradiation effect occurs in rat peripheral nerves4. Changes in nuclear population were studied after sciatic nerve crush.
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References
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CAVANAGH, J. Effects of Previous X-irradiation on the Cellular Response of Nervous Tissue to Injury. Nature 219, 626–627 (1968). https://doi.org/10.1038/219626a0
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DOI: https://doi.org/10.1038/219626a0
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