Abstract
FREEZING temperatures have been in use in surgery for many years as a means of local tissue destruction. Recent experimental investigation has shown that such freezing will give a reproducible area of cell death provided factors such as the temperature and the duration of application are constant. Additional virtues have been claimed for repeated, as opposed to single, freeze–thaw cycles in terms of the degree of tissue destruction. In his discussion on cryotherapy for oral cancer Gage1 states “repetition of the freeze will increase the certainty of cell destruction” and similar comments2,3 are frequent in the literature.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Gage, A. A., Koepf, S., Wehrle, D., and Emmings, F., Cancer, 18, 1646 (1965).
Cahan, W. G., Fed Proc., 24, 241 (1965).
Cooper, I. S., Fed. Proc., 24, 237 (1965).
Fraser, J., and Gill, W., Brit. J. Surg., 54, 770 (1967).
Heard, B. E., Brit. J. Surg., 42, 659 (1955).
Trump, B. F., Young, D. E., Arnold, E. A., and Stowell, R. E., Fed. Proc., 24, 5, 144 (1965).
Stowell, R. E., Young, D. E., Arnold, E. A., and Trump, B. F., Fed. Proc., 24, 115 Suppl. 15 (1965).
Spells, K. E., J. Phys. Med. Biol., 5, 139 (1960).
Ponder, E., J. Gen. Physiol., 45, 545 (1962).
Meryman, H. T., Cryobiology (edit. by Meryman, H. T.), 40 (Academic Press, London and New York, 1960).
Poppendiek, H. F., Randall, R., Breeden, J. A., Chambers, J. E., and Murphy, J. R., Cryobiology, 3, 4, 318 (1967).
Meryman, H. T., Cryobiology (edit. by Meryman, H. T.), 27 (Academic Press, London and New York, 1966).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
GILL, W., FRASER, J. & CARTER, D. Repeated Freeze–Thaw Cycles in Cryosurgery. Nature 219, 410–413 (1968). https://doi.org/10.1038/219410a0
Received:
Revised:
Published:
Issue Date:
DOI: https://doi.org/10.1038/219410a0
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
