Abstract
STUDIES of subcellular systems of resistant E. coli K-12 (ref. 1) and staphylococci2 have proved that the basis of chloramphenicol resistance in these bacteria is their ability to acetylate the drug. These results agreed with Miyamura's report3 on the relationship between the resistance to chloramphenicol of naturally isolated enterobacteria carrying R-factor and of staphylococci and their ability to inactivate the drug.
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References
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GARBER, N., ZOHAR, D. & MICHLIN, H. Rapid Chemical Determination of Chloramphenicol Acetylation by Cell Extracts and by Cell Suspensions of E. coli B. Nature 219, 401–402 (1968). https://doi.org/10.1038/219401a0
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DOI: https://doi.org/10.1038/219401a0
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