Abstract
INDIRECT evidence indicates that the 2′-hydroxyl group of the ribose moiety may play an important part in determining the structural properties of nucleic acids in solution. The formation and stability of helical structures formed by the aggregation of 5′-guanylic acid1, by single stranded oligonucleotides2–4, homopolymers5 and by double stranded structures6 depend on the presence or absence of 2′-OH. All these results were explained by the formation of a hydrogen bond in which the 2′-OH group is interacting either with the neighbouring base5 or with the phosphate oxygen1–2.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Brahms, J., and Sadron, C., Nature, 202, 1309 (1966).
Brahms, J., Maurizot, J. C., and Michelson, A. M., J. Mol. Biol., 25, 481 (1967).
Adler, A., Grossman, L., and Fasman, G. D., Proc. US Nat. Acad. Sci., 57, 423 (1967).
Vournakis, J., Poland, D., and Scheraga, H. A., Biopolymers, 5, 403 (1967).
Ts'o, P. O. P., Rapaport, S. A., and Bollum, F. J., Biochemistry, 5, 4153 (1966).
Chamberlin, M. J., Fed. Proc., 24, 1446 (1965).
Wechter, W. J., J. Med. Chem., 10, 762 (1967).
Wechter, W. J., Mikulski, A. J., and Laskowski, M. Sr., Biochem. Biophys. Res. Commun., 30, 318 (1968).
Arnott, S., Wilkins, M. H. F., Fuller, W., Venable, J. H., and Langridge, R., J. Mol. Biol., 27, 549 (1967).
Tinoco, jun., I., J. Amer. Chem. Soc., 86, 297 (1964).
Bush, C. A., and Brahms, J., J. Chem. Phys., 46, 79 (1967).
Ulbricht, T. L. V., Emerson, T. R., and Swan, R. J., Biochem. Biophys. Res. Commun., 19, 643 (1965).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
MAURIZOT, J., WECHTER, W., BRAHMS, J. et al. Comparison of Conformational Characteristics of Arabinose and Ribose containing Dinucleoside Phosphates. Nature 219, 377–379 (1968). https://doi.org/10.1038/219377a0
Received:
Revised:
Published:
Issue Date:
DOI: https://doi.org/10.1038/219377a0
This article is cited by
-
The stabilisation of nucleic acid structures
Biophysik (1970)
-
Forces involved in the Conformational Stability of Nucleic Acids
Nature (1969)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
