Abstract
THE initiation of a primary immune response seems to depend on the phagocytosis of antigen by the macrophage. The antigen is processed in some way by the macrophage to yield an RNA-antigen complex that stimulates potential immunocompetent lymphocytic cells to synthesize specific antibody1–9. We have examined the requirement of the macrophage in subsequent responses to the same antigen.
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References
Fishman, M., J. Exp. Med., 114, 837 (1961).
Fishman, M., Hammerstrom, R. A., and Bond, V. P., Nature, 198, 549 (1963).
Fishman, M., and Adler, F. L., J. Exp. Med., 117, 595 (1963).
Askonas, B. A., and Rhodes, J. M., Nature, 205, 470 (1965).
Friedman, H. P., Stavitsky, A. B., and Solomon, J. M., Science, 149, 1106 (1965).
Adler, F. L., Fishman, M., and Dray, S., J. Immunol., 97, 554 (1966).
Cohen, E. P., Nature, 213, 462 (1967).
Gottlieb, A. A., Glisin, V. R., and Doty, P., Proc. US Nat. Acad. Sci., 57, 1849 (1967).
Bishop, D. C., Pisciotta, A. V., and Abramoff, P., J. Immunol., 99, 751 (1967).
Rabinowitz, Y., Blood, 23, 811 (1964).
Killander, J., Pontén, J., and Rodén, L., Nature, 192, 182 (1961).
Sainte-Marie, G., J. Histochem. Cytochem., 10, 250 (1962).
Stavitsky, A. B., and Gusdon, J. P., Bact. Rev., 30, 418 (1966).
Nowell, P. C., Cancer Res., 20, 462 (1960).
Nowell, P. C., Blood, 26, 798 (1965).
Robbins, J. H., Science, 146, 1648 (1964).
Coulson, A. S., and Chalmers, D. G., Lancet, ii, 819 (1964).
Sell, S., and Gell, P. G. H., J. Exp. Med., 122, 423 (1965).
Harris, G., Nature, 211, 154 (1966).
Perkins, E. H., and Makinodan, T., J. Immunol., 94, 765 (1965).
Harris, G., Immunology, 9, 529 (1965).
Parkhouse, R. E. M., and Dutton, R. W., J. Immunol., 97, 663 (1966).
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MOORE, R., SCHOENBERG, M. Restimulation of Antibody Synthesis by Antigen in Cultures of Lymphocytes. Nature 219, 297–298 (1968). https://doi.org/10.1038/219297a0
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DOI: https://doi.org/10.1038/219297a0
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