Abstract
THE regulation of enzyme activity by cellular metabolites in micro-organisms is usually exerted by feedback control, an initial enzyme of a pathway being controlled by an end-product of that pathway. Such control of enzyme activity has, in many cases, been shown to be “allosteric”—that is, the end-product effector binds to the enzyme at a site distinct from the catalytic (active) site. The modifying effect on enzyme activity probably results from an induced conformational change in the enzyme structure.
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References
Krebs, H. A., and Lowenstein, J. M., in Metabolic Pathways (edit. by Greenberg, D. M.), 1, 129 (Academic Press, New York and London, 1960).
Hathaway, J. A., and Atkinson, D. E., Biochem. Biophys. Res. Commun., 20, 661 (1965).
Bogin, E., and Wallace, A., Biochim. Biophys. Acta, 128, 190 (1966).
Shepherd, D., and Garland, P. B., Biochem. Biophys. Res. Commun., 22, 89 (1966).
Jangaard, N. O., Unkeless, J., and Atkinson, D. E., Biochim. Biophys. Acta, 151, 225 (1968).
Weitzman, P. D. J., Biochim. Biophys. Acta, 128, 213 (1966).
Weitzman, P. D. J., Biochem. J., 101, 44c (1966).
Srere, P. A., Brazil, H., and Gonen, L., Acta Chem. Scand., 17, S129 (1963).
Weitzman, P. D. J., Biochem. J., 99, 18P (1966).
Salton, M. R. J., The Bacterial Cell Wall (Elsevier, Amsterdam, 1964).
Rogers, H. J., and Perkins, H. R., in Cell Walls and Membranes (edit. by Long, C.) (E. and F. N. Spon, Ltd, London, 1968).
Fitz-James, P. C., J. Biophys. Biochem. Cytol., 8, 507 (1960).
Glauert, A. M., Brit. Med. Bull., 18, 245 (1962).
Mitchell, P., Biochem. Soc. Symp., 22, 142 (1963).
Atkinson, D. E., and Walton, G. M., J. Biol. Chem., 240, 757 (1965).
Maeba, P., and Sanwal, B. D., J. Biol. Chem., 243, 448 (1968).
Sneath, P. H. A., and Cowan, S. T., J. Gen. Microbiol., 19, 551 (1958).
Wang, C. H., in Taxonomic Biochemistry and Serology (edit. by Leone C. A.) (Ronald Press Co., New York, 1964).
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WEITZMAN, P., JONES, D. Regulation of Citrate Synthase and Microbial Taxonomy. Nature 219, 270–272 (1968). https://doi.org/10.1038/219270a0
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DOI: https://doi.org/10.1038/219270a0
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