Abstract
ACCORDING to Torack and Barrnett1 the activity of 5-nucleoside phosphatase in the brain capillaries is localized in the basement membrane of the capillary wall and in the surface membranes of the glial end feet surrounding the capillaries. Thus with respect to the fine structural localization of the activity of adenosine triphosphatase (ATPase) the capillaries of the brain differ markedly from those of other tissues in which ATPase activity is located in the pinocytotic vesicles of the endothelial cytoplasm. By means of a sensitive method based on the fluorescence of trypan blue it has previously been shown2 that when ATPase is inhibited the permeability of the haematoencephalic barrier is enhanced. Thus it seems that the activity of ATPase in the brain capillaries does not indicate the site of accelerated transport—as Barrnett suggested3. The activity of this enzyme is, however, in close correlation with the specific functions of the blood–brain barrier.
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References
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JOÓ, F. Effect of Inhibition of Adenosine Triphosphatase Activity on the Fine Structural Organization of the Brain Capillaries. Nature 219, 1378–1379 (1968). https://doi.org/10.1038/2191378a0
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DOI: https://doi.org/10.1038/2191378a0
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