Abstract
NORADRENALINE is a neurotransmitter at synapses of the peripheral sympathetic nervous system and, possibly, in the brain1–3. After liberation at synapses this amine is inactivated presumably by re-uptake into nerve terminals1–4. Exogenous noradrenaline which has been taken up by noradrenergic nerve terminals mixes in the storage granules with endogenous amine5,6. This uptake process has been examined in vivo by measuring the accumulation of noradrenaline-H3 into peripheral sympathetically innervated organs after systemic administration7 or into the brain after intraventricular injection8,9. Brain slices incubated in oxygenated physiological media also concentrate noradrenaline into nerve endings10,11.
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SNYDER, S., GREEN, A., HENDLEY, E. et al. Noradrenaline: Kinetics of Accumulation into Slices from Different Regions of Rat Brain. Nature 218, 174–176 (1968). https://doi.org/10.1038/218174a0
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DOI: https://doi.org/10.1038/218174a0
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