Abstract
THE thymus has been reported to be important in the development of the immunological capacities of several animal species, so that neonatal thymectomy impairs many kinds of immune responses. On the other hand, there have been few reports of the effects of thymectomy on the function of the macrophage, which is known to be involved in immune responses. No differences have been detected between the reticuloendothelial phagocytic activity of neonatally thymectomized and control animals in response to colloidal gold1 and carbon2. On the other hand, Corsi and Giusti3 reported that although a single injection of colloidal carbon made no difference to either group of rats, after a second injection carbon was removed more quickly in the thymectomized rats. While investigating the infection of thymectomized mice with Listeria monocytogenes4, we observed a phenomenon which may indicate that macrophage function is modified by neonatal thymectomy.
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References
Salvin, S. B., Peterson, R. D. A., and Good, R. A., J. Lab. Clin. Med., 65, 1004 (1965).
Morrow, S. H., and Di Luzio, N. R., Nature, 205, 193 (1965).
Corsi, A., and Giusti, G. V., Nature, 213, 618 (1967).
Takeya, K., Mori, R., and Nomoto, K., Proc. Japan Acad., 40, 769 (1964).
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TAKEYA, K., MORI, R. & IMAIZUMI, N. Suppressed Multiplication of Listeria monocytogenes within Macrophages derived from Thymectomized Mice. Nature 218, 1174 (1968). https://doi.org/10.1038/2181174a0
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DOI: https://doi.org/10.1038/2181174a0
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