Abstract
Globus and Kuhlenbeck1,2 drew attention to the presence beneath the lining of the cerebral ventricles of a distinct cell layer, which they named the subependymal cell plate. They demonstrated it in the brain of human infants, showed it to contain primitive cells and stressed its possible role in the development of certain paraventricular neoplasms. Various workers3–5 have shown the persistence of a subependymal layer in man from foetal to adult life, but except for explaining the origin of “subependymomas”6 the idea that this zone plays a part in the genesis of gliomas has met with little support.
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References
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LEWIS, P. Mitotic Activity in the Primate Subependymal Layer and the Genesis of Gliomas. Nature 217, 974–975 (1968). https://doi.org/10.1038/217974a0
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DOI: https://doi.org/10.1038/217974a0
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