Abstract
Wyllie, Limbosch and Nyhus1, in commenting on the results of Baume, Nicholls and Baxter2, state that the inhibition of gastric secretion by lipopolysaccharide “was clearly described in 1950” by Blickenstaff and Grossman3. Blickenstaff and Grossman used ‘Pyromen’, a commercially available pyrogen (Nesset et al.4), which is very impure and only partially characterized. It was for this reason that their results were not discussed by Baume et al.2 in their brief communication.
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References
Wyllie, J. H., Limbosch, J. M., and Nyhus, L. M., Nature, 215, 879 (1967).
Baume, P. E., Nicholls, A., and Baxter, C. H., Nature, 215, 59 (1967).
Blickenstaff, D., and Grossman, M. I., Amer. J. Physiol., 160, 567 (1950).
Nesset, N. M., McLallen, J., and Anthony, P. Z., J. Amer. Pharm. Ass., 39, 456 (1950).
Taylor, A., Knox, K. W., and Work, E., Biochem. J., 99, 53 (1966).
Knox, K. W., Cullen, J., and Work, E., Biochem. J., 103, 192 (1967).
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BAUME, P. Pyrogenicity of ‘Pyromen’. Nature 217, 970 (1968). https://doi.org/10.1038/217970a0
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DOI: https://doi.org/10.1038/217970a0
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