Abstract
THE mouse mutant “nude” has been described by Flanagan1. It is an autosomal recessive. The homozygotes, nu nu, are hairless and their growth is retarded. More than half die before weaning and none survives for as long as 25 weeks. Other parts of the syndrome were: sulphydryl group deficiency and abnormal keratinization of hair follicles, and necrosis of the liver, associated with Toxoplasma gondii infection. No single primary defect of development responsible for these pleiotropic effects could be suggested.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Flanagan, S. P., Genet. Res., 8, 295 (1966).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
PANTELOURIS, E. Absence of Thymus in a Mouse Mutant. Nature 217, 370–371 (1968). https://doi.org/10.1038/217370a0
Received:
Issue Date:
DOI: https://doi.org/10.1038/217370a0
This article is cited by
-
Genetically modified mice as a tool for the study of human diseases
Molecular Biology Reports (2024)
-
MYC overexpression and SMARCA4 loss cooperate to drive medulloblastoma formation in mice
Acta Neuropathologica Communications (2023)
-
Contributions of Age-Related Thymic Involution to Immunosenescence and Inflammaging
Immunity & Ageing (2020)
-
An enolase inhibitor for the targeted treatment of ENO1-deleted cancers
Nature Metabolism (2020)
-
Immune-relevant aspects of murine models of head and neck cancer
Oncogene (2019)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.