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Lack of Complement Fixing Antigens in DMBA-induced Leukaemia of Rats

Nature volume 217, pages 363–364 (1968)Cite this article

Abstract

MOUSE leukaemia viruses have not induced overt cytopathic effects in tissue cultures and so the complement fixation technique has been used to detect virus antigens in tissue cultures1. The technique involved sera of rats which were carrying transplanted tumours originally induced by leukaemogenic virus, and extracts of rat tumours. Germ-free and normal rats developed lesions of myelogenous leukaemia after repeated intraperitoneal administrations of sterile 7,12-dimethylbenz(a)anthracene (DMBA) in fat2,3. Viral flora could not be detected in their tissues by electron microscopy, nor by other extensive examinations4. This communication describes the use of the complement fixation technique in a search for disease-related antigens in rats with DMBA-induced leukaemia.

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Authors and Affiliations

  1. Lobund Laboratory, University of Notre Dame, Notre Dame, Indiana

    NEHAMA SHARON & MORRIS POLLARD

Authors
  1. NEHAMA SHARON
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  2. MORRIS POLLARD
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SHARON, N., POLLARD, M. Lack of Complement Fixing Antigens in DMBA-induced Leukaemia of Rats. Nature 217, 363–364 (1968). https://doi.org/10.1038/217363a0

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  • DOI: https://doi.org/10.1038/217363a0

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