Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Detection of Insulin Precipitating Antibodies

Nature volume 217, pages 356–357 (1968)Cite this article

Abstract

THERE are various immunological techniques for detecting antibodies to peptide antigens, but the detection of precipitating antibodies to small peptide hormones which are poor antigens may be difficult. Preparations of crystalline insulin from a variety of species are quite similar and only a few differences in amino-acid composition have been found, which in addition to the smaller molecular size may account for its poor antigenicity. Nevertheless, the Ouchterlony technique1 has revealed precipitating antibodies to insulin (for example, refs. 2–5).

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Ouchterlony, O., Acta Pathol. Microbiol. Scand., 25, 186 (1948).

    Article  CAS  Google Scholar 

  2. Moloney, P. J., and Aprile, M. A., Canad. J. Biochem. Physiol., 37, 793 (1959).

    Article  CAS  Google Scholar 

  3. Jones, V. E., and Cunliffe, A. C., Nature, 192, 136 (1961).

    Article  ADS  CAS  Google Scholar 

  4. Steigerwald, H., Spielman, W., Fries, H., and Grebe, S. T., Klin. Woch., 38, 973 (1960).

    Article  CAS  Google Scholar 

  5. Birkinshaw, V. J., Randall, S. S., and Risdall, P. C., Nature, 193, 1089 (1962).

    Article  ADS  CAS  Google Scholar 

  6. Grabar, P., and Williams, C. A., Biochim. Biophys. Acta, 10, 193 (1953).

    Article  CAS  Google Scholar 

  7. Grabar, P., and Williams, C. A., Biochim. Biophys. Acta, 17, 67 (1955).

    Article  CAS  Google Scholar 

  8. Wide, L., and Porath, J., Biochim. Biophys. Acta, 130, 257 (1966).

    Article  CAS  Google Scholar 

  9. Ogston, A. G., and Phelps, C. F., Biochem. J., 78, 827 (1961).

    Article  CAS  Google Scholar 

  10. Laurent, T. C., Biochem. J., 89, 253 (1963).

    Article  CAS  Google Scholar 

  11. Laurent, T. C., Acta Chem. Scand., 17, 2664 (1963).

    Article  CAS  Google Scholar 

  12. Hellsing, K., and Laurent, T. C., Acta Chem. Scand., 18, 1303 (1964).

    Article  CAS  Google Scholar 

  13. Iverius, P. H., and Laurent, T. C., Biochim. Biophys. Acta, 133, 371 (1967).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Biochemistry, Pharmacia AB, Uppsala, Sweden

    M. CESKA

Authors
  1. M. CESKA
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

CESKA, M. Detection of Insulin Precipitating Antibodies. Nature 217, 356–357 (1968). https://doi.org/10.1038/217356a0

Download citation

  • Received:

  • Revised:

  • Issue Date:

  • DOI: https://doi.org/10.1038/217356a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing