Abstract
WE have reported a discrimination between the ratio of strontium to calcium in rabbit plasma and that in bone1. We reasoned that this discrimination could be the result of a difference in this ratio in the protein and non-protein fractions of the plasma. If the ratio of strontium to calcium in the non-protein fractions was lower than that in the plasma as a whole, then the ratio in the extracellular fluid might be expected to be lower and hence account for the lower ratio which has been observed in bone. To test this hypothesis a double tracer experiment using strontium-85 and calcium-47 was carried out in two rabbits which were of the same strain and age (7 months) as those used before. The protein and non-protein fractions were separated in an ultracentrifuge and the ratio of strontium-85 to calcium-47 was determined for these fractions as well as for the whole serum. These measurements showed that the ratio was the same for all fractions within the limits of experimental error.
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References
Kshirsagar, S. G., Lloyd, E., and Vaughan, J., Brit. J. Radiol., 39, 131 (1966).
Breen, M., and Freeman, S., Clin. Chim. Acta, 6, 181 (1961).
Munday, K. A., and Mahy, B. W. J., Clin. Chim. Acta, 10, 144 (1964).
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LLOYD, E. Relative Binding of Strontium and Calcium in Protein and Non-protein Fractions of Serum in the Rabbit. Nature 217, 355–356 (1968). https://doi.org/10.1038/217355a0
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DOI: https://doi.org/10.1038/217355a0
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