Abstract
BECAUSE the antibacterial agent, tetramethyldipicrylamine, which we reported recently1 has aroused wide interest we have developed a modification in the synthesis of the intermediate, 3,3′,5,5′-tetramethyldiphenylamine, which will make it possible for research workers to prepare experimental quantities of pure material in good yield without the necessity of elaborate equipment. The methods reported previously involved heating 3,5-dimethylaniline and its hydrochloride in either a glass2 or metal3 autoclave at 235°–250° C or heating a mixture of 3,5-dimethylaniline and 3,5-dimethylphenol at 300°–400° C under 50 to 300 atmospheres pressure4.
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FRITSCH, A., MOORE, C. & MEYER, T. Simplification of the Synthesis of Tetramethyldipicrylamine. Nature 217, 350 (1968). https://doi.org/10.1038/217350a0
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DOI: https://doi.org/10.1038/217350a0
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