Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Regional Distribution of Tritiated Acetylcholine in Rat Brain

Nature volume 217, pages 184–185 (1968)Cite this article

Abstract

THE almost universal occurrence of acetylcholine, other choline derivatives and cholinesterase in the vertebrate nervous system, and effects of cholinesterase inhibitors on the central nervous system have suggested that cholinergic systems play an important part in brain function. The experimental evidence for such a role ranges from effects on the rate of discharge of single brain neurones to complex animal behaviour1. Whittaker2 has demonstrated that acetylcholine is located primarily in the specific tissue fraction consisting chiefly of nerve ending particles. De Robertis3 has located acetylcholine in the synaptic vesicles recovered from brain homogenates.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Votava, Z., Ann. Rev. Pharmacol., 7, 223 (1967).

    Article  CAS  Google Scholar 

  2. Whittaker, V. P., in Progress in Brain Research, 8: Biogenic Amines (edit. by Himwich, H. E.), 90 (Elsevier Publishing Co., New York, 1964).

    Book  Google Scholar 

  3. De Robertis, E., in Progress in Brain Research, 8: Biogenic Amines (edit. by Himwich, H. E.), 118 (Elsevier Publishing Co., New York, 1964).

    Google Scholar 

  4. Bhagat, B., and Pradhan, S. N., Pharmacologist, 8, 188 (1966).

    Google Scholar 

  5. Hebb, C. O., Morris, D., and Bull, G., Nature, 207, 1295 (1965).

    ADS  PubMed  Google Scholar 

  6. Burton, R. M., Intern. J. Neuropharmacol., 3, 13 (1964).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pharmacology, New York Medical College, New York, 10029

    S. Z. KRAMER, J. SEIFTER & B. BHAGAT

Authors
  1. S. Z. KRAMER
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. J. SEIFTER
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. B. BHAGAT
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

KRAMER, S., SEIFTER, J. & BHAGAT, B. Regional Distribution of Tritiated Acetylcholine in Rat Brain. Nature 217, 184–185 (1968). https://doi.org/10.1038/217184a0

Download citation

  • Received:

  • Revised:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/217184a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing