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Regeneration of a Peripheral Nerve Implant into Goldfish Telencephalic Parenchyma

Abstract

THE nerve fibres of a peripheral nerve implanted in the cortex of the rat1 or cat2,3 do not regenerate into the brain parenchyma. The glial scar which lines the wound made in the parenchyma during nerve implantation seems to be a mechanical barrier to successful regeneration. After nerve implantation and administration of the drug piromen, however, the peripheral axons which formerly had not grown through the glial scar now grow through the scar2,3.

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References

  1. LeGros Clark, W. E., J. Anat., 77, 251 (1943).

    CAS  Google Scholar 

  2. Clemente, C. D., in Regeneration in the Central Nervous System, 147 (Thomas, Springfield, Illinois, 1955).

    Google Scholar 

  3. Windle, W. F., Clemente, C. D., and Chambers, W. W., J. Comp. Neurol., 96, 359 (1952).

    Article  CAS  Google Scholar 

  4. Scott, D., and Liu, C. N., Prog. Brain Res., 13, 127 (1964).

    Article  Google Scholar 

  5. Bernstein, J. J., Exp. Neurol., 17, 44 (1967).

    Article  CAS  Google Scholar 

  6. Bernstein, J. J., and Bernstein, M. E., Exp. Neurol., 19, 25 (1967).

    Article  CAS  Google Scholar 

  7. Robertson, J. D., Bodenheimer, T. S., and Stage, D. E., J. Cell Biol., 19, 159 (1963).

    Article  CAS  Google Scholar 

  8. Palay, S. L., McGee-Russell, S., Gordon, S., and Grillo, M. A., J. Cell Biol., 12, 385 (1962).

    Article  CAS  Google Scholar 

  9. Goodman, D. C., and Horel, J. A., J. Comp. Neurol., 126, 71 (1965).

    Google Scholar 

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BERNSTEIN, J. Regeneration of a Peripheral Nerve Implant into Goldfish Telencephalic Parenchyma. Nature 217, 183–184 (1968). https://doi.org/10.1038/217183a0

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  • DOI: https://doi.org/10.1038/217183a0

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