Abstract
ANTILYMPHOCYTE serum (ALS) and globulin (ALG) are potent suppressors of certain forms of immune response, particularly homograft rejection1,2 and the primary antibody response3. Their mode of action has, however, been disputed. Although lymphopenia has been considered the essential cause of the immunosuppression4 it has not always accompanied homograft acceptance which is induced by these agents2,5. “Blind-folding” and “sterile blast activation” of lymphocytes by ALG have been proposed as alternative mechanisms2. It has also been observed that renal homografts which have escaped rejection can nevertheless be infiltrated by lymphocytes, suggesting that the progeny of lymphoid cells exposed to ALG function inadequately6.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Woodruff, M. F. A., and Anderson, N. F., Ann. NY Acad. Sci., 120, 119 (1964).
Levey, R. H., and Medawar, P. B., Ann. NY Acad. Sci., 129, 164 (1966).
James, K., and Anderson, N. F., Nature, 213, 1195 (1967).
Kinne, D. W., and Simmons, R. L., J. Immunol., 98, 251 (1967).
Anderson, N. F., James, K., and Woodruff, M. F. A., Lancet, i, 1126 (1967).
Starzl, T. E., Marchioro, T. L., Porter, K. A., Iwasaki, Y., and Cerilli, G. L., Surgery Gynec. Obstet., 124, 301 (1967).
Denman, A. M., and Frenkel, E. P., Immunology, 14, 107, 115 (1968).
Denman, A. M., Frenkel, E. P., and Ziff, M., Proc. Soc. Exp. Biol. Med., 125, 1127 (1967).
Hildemann, W. H., Linscott, W. D., and Morlina, M. J., in Ciba Foundation Symposium on Transplantation, 236 (Churchill, London, 1962).
Ford, W. L., and Gowans, J. L., Proc. Roy. Soc., B, 168, 244 (1967).
Frenkel, E. P., Sugino, Y., Bishop, R., and Potter, R. L., Rad. Res., 19, 701 (1963).
Bessis, M., Cytology of the Blood and Blood Forming Organs (Grune and Stratton, New York, 1956).
Denman, A. M., and Frenkel, E. P., J. Immunol., 99, 498 (1967).
Levey, R. H., and Medawar, P. B., Proc. US Nat. Acad. Sci., 58, 470 (1967).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
DENMAN, A., DENMAN, E. & HOLBOROW, E. Immunosuppressive Effects of Lymphoid Cell Proliferation in Mice receiving Anti-lymphocyte Globulin. Nature 217, 177–178 (1968). https://doi.org/10.1038/217177a0
Received:
Revised:
Published:
Issue Date:
DOI: https://doi.org/10.1038/217177a0
This article is cited by
-
Mitoseaktivit�t und Chromosomenanalyse in peripheren Lymphocyten ALG-behandelter Patienten
Klinische Wochenschrift (1970)
-
Untersuchungen zur Wirkung von Antilymphocytenglobulin bei der experimentellen allergischen Encephalomyelitis des Meerschweinchens
Klinische Wochenschrift (1970)
-
Ultrastrukturelle Zell- und Organveränderungen nach Verabreichung eines heterologen Antilymphozytenserums (ALS) bei der Ratte. II. ALS-Inkubation in vitro von Ductus-thoracicus-Zellen ALS-behandelter Ratten
Blut Zeitschrift für die Gesamte Blutforschung (1970)
-
Improved Graft Survival after Treatment with Bordetella and Anti-lymphocyte Serum
Nature (1969)
-
Wirkung eines heterologen Antilymphocytenserums auf die experimentelle allergische Encephalomyelitis
Klinische Wochenschrift (1969)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
