Abstract
THE theory that the DNA content of cells remains constant has been widely accepted, but some workers1–3 presume that DNA content decreases either during the mitosis of the precursor cell (hypoploidy4, haploidy5) or during the interphase maturation of the myelocyte stage into the granulocyte stage. Another open question is: which myeloid cells are capable of DNA synthesis and mitosis? Most authors express the belief that these are the myeloblasts, promyelocytes and myelocytes6,7. Recent evidence, however, indicates that some metamyelocytes can synthesize DNA. This has been shown in the bone marrow of the guinea-pig after haemorrhage, by labelling with 3H-thymidine and by cytophotometry8; in irradiated rats as well as normal rats, by autoradiographic methods9; and in humans, by cinematomicrography10.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Marinone, G., Rev. d'Hématol., 9, 341 (1954).
Hale, A. J., in VIII Kongress d. Europ. Ges. f. Haematologie, Vienna (1961).
Müller, D., Klin. Wschr., 42, 224 (1964).
Kinosita, R., and Ohno, S., Naturwissenschaften, 41, 381 (1954).
Miyoshi, K., and Kono, H., Tokushima J. Exp. Med., 7, 196 (1960).
Patt, H. M., and Maloney, M. A., Ann. NY Acad. Sci., 113, 515 (1964).
Schumacher, H. R., and Erslev, A. J., in Nuclear Haematology (edit. by Szirmai, E.), 89 (Academic Press, New York–London, 1965).
Harris, P. F., and Kugler, J. H., Exp. Cell Res., 42, 196 (1966).
Lord, B. I., Brit. J. Haematol., 11, 130 (1965).
Boll, I., Granulocytopoese unter physiologischen und pathologischen Bedingungen (Springer, Berlin–Heidelberg–New York, 1966).
Balázs, A., and Rappay, G., Acta Biol. Hung., 17, 256 (1967).
Lennartz, K. J., Schümmelfeder, N., and Maurer, W., Naturwissenschaften, 53, 21 (1966).
Strickmans, P., Cronkite, E. P., Fliedner, T. M., and Ramos, J., Nature, 211, 717 (1966).
Garcia, A. M., Acta Histochem., 17, 246 (1964).
Gelfant, S., Exp. Cell Res., 26, 395 (1962).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
BALÁZS, A., RAPPAY, G. DNA Dynamics in Rat Granulopoiesis studied by Cytophotometry. Nature 217, 166–168 (1968). https://doi.org/10.1038/217166a0
Received:
Revised:
Published:
Issue Date:
DOI: https://doi.org/10.1038/217166a0
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
