Abstract
A NUMBER of reports1–5 have described the effects of enzymes on the mechanical responses of isolated muscles obtained in response to drugs and other stimuli. Enzyme treatment, however, does not always provide a way of examining the nature of drug receptors because the drug receptor interaction is only the first of a chain of events leading to contraction. If the predominant enzyme effect is on a stage of the process following the drug receptor interaction, no information about the nature of the receptor can be adduced. In such cases a proportional reduction in the response to several different stimuli might be expected. We wish to present our own findings as a case in point.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Cuthbert, A. W., J. Pharm. Pharmacol., 18, 561 (1966).
Edery, H., J. Pharmacol., 22, 371 (1964).
Graham, J. D. P., and Alkatib, H., Brit. J. Pharmacol., 28, 1 (1966).
Lu, F. C., Brit. J. Pharmacol., 7, 637 (1952).
Wooley, D. W., and Gommi, B. W., Nature, 202, 1074 (1964).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
GROSSMAN, M., KALOW, W. & COOPER, P. Effects of Enzymes on the Pharmacology of Isolated Organs. Nature 217, 1151–1152 (1968). https://doi.org/10.1038/2171151a0
Received:
Issue Date:
DOI: https://doi.org/10.1038/2171151a0
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.