Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Influence of Hypoxia on Glucose Transport across the Human Placenta

Abstract

EXPERIMENTAL models for foetal hypoxia have predominantly employed acute asphyxiation1,2, although in the human it is likely that when impairment of foetal oxygenation does occur it is often chronic and incomplete3. It has been shown4 that by giving mothers 10 per cent oxygen to breathe (for short periods of time) it is possible to halve foetal oxygen tension without harming the foetus. This experimental technique was used to study glucose and acid-base status in mother and foetus during hypoxia.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Jacobson, H. N., and Windle, W. F., J. Physiol., 153, 447 (1960).

    Article  CAS  Google Scholar 

  2. Adamsons, K., Behrman, R., Dawes, G. S., James, L. S., and Koford, C., J. Pediat., 65, 807 (1964).

    Article  Google Scholar 

  3. Towell, M. E., Pediat. Clins. N. Amer., 13, 575 (1966).

    Article  CAS  Google Scholar 

  4. Newman, W., McKinnon, L., Phillips, L., Paterson, P., and Wood, C., Amer. J. Obstet. Gynec. (in the press).

  5. Saling, E. J., Intern. Fed. Oynaec. Obstet., 3, 101 (1965).

    Google Scholar 

  6. Severinghaus, J. W., J. Appl. Physiol., 21, 1108 (1966).

    Article  CAS  Google Scholar 

  7. Keston, A. S., Abstracts of Papers at 129th Meeting Amer. Cancer Soc., 31C (1956).

  8. Teller, J. D., Abstracts of Papers at 130th Meeting Amer. Cancer Soc., 69C (1956).

  9. Keele, D. K., Kay, J. L., Brown, J., and Nordquist, B., Pediatrics, 37, 597 (1966).

    CAS  PubMed  Google Scholar 

  10. Paterson, P., Phillips, L., and Wood, C., Amer. J. Obstet. Gynec. (in the press).

  11. Ely, P. A., J. Physiol., 184, 255 (1966).

    Article  CAS  Google Scholar 

  12. Battaglia, F. C., Meschia, G., Hellegers, A., and Barron, D. H., Quart. J. Exp. Physiol., 43, 197 (1958).

    Article  CAS  Google Scholar 

  13. Huckabee, W. E., J. Clin. Invest., 37, 264 (1958).

    Article  CAS  Google Scholar 

  14. Cross, K. W., Flynn, D. M., and Hill, J. R., Pediatrics, 37, 565 (1966).

    CAS  PubMed  Google Scholar 

  15. Karvonen, M. J., Laamen, A., and Raihã, N., Acta Physiol. Scand., 36, 245 (1956).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

LUMLEY, J., WOOD, C. Influence of Hypoxia on Glucose Transport across the Human Placenta. Nature 216, 403–404 (1967). https://doi.org/10.1038/216403a0

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/216403a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing