Abstract
THE “minimal deviation” hepatomas—well differentiated rat hepatocellular carcinomas—demonstrate many abnormal enzyme regulatory mechanisms1. It has been suggested that these alterations are critical in neoplastic transformation2. The corticosteroid induction of the hepatic enzymes tryptophan pyrrolase (TP) and tyrosine transaminase (TT) has been extensively studied in these tumours1. Administration of corticosteroid causes a considerable increase in the activities of TP and TT in the normal adult rat liver within 4–5 h (refs. 3 and 4). In hepatomas, however, there is little or no increase in TP activity after administration of corticosteroid, and baseline enzyme activity is usually depressed1.
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TEEBOR, G., BECKER, F. & SEIDMAN, I. Hydrocortisone Induction of Tyrosine Transaminase in Regenerating Rat Liver. Nature 216, 396–397 (1967). https://doi.org/10.1038/216396a0
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DOI: https://doi.org/10.1038/216396a0
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