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Effect of Arterial Oxygen on Mammalian Brain Oxygen Tension

Nature volume 216, pages 295–297 (1967)Cite this article

Abstract

EXPOSURE to one atmosphere of oxygen has been found to cause changes similar to retrolental fibroplasia in the cerebral cortex of newborn mice1, and exposure to oxygen at pressure greater than 2.5 atm. can often cause a grand mal type of convulsion in mature mammals2. The nature of such oxygen toxicity is unknown, and studies of the effect of this gas on various tissues have been hampered by the inability to monitor directly the oxygen tension in a tissue with accuracy.

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Author information

Author notes

  1. C. CHARLTON

    Present address: Department of Bacteriology, University of Sydney, Australia

Authors and Affiliations

  1. National Institute of Mental Health, Bethesda, Maryland

    CARL R. MERRIL

  2. National Institute of Dental Research, Bethesda, Maryland

    C. CHARLTON

  3. National Institute of Neurological Diseases and Blindness, Bethesda, Maryland

    P. YARNELL & A. K. OMMAYA

Authors
  1. CARL R. MERRIL
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  2. C. CHARLTON
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  3. P. YARNELL
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  4. A. K. OMMAYA
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MERRIL, C., CHARLTON, C., YARNELL, P. et al. Effect of Arterial Oxygen on Mammalian Brain Oxygen Tension. Nature 216, 295–297 (1967). https://doi.org/10.1038/216295a0

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