Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Determination of Switching-off and Switching-on Time of Overall Nuclear RNA Synthesis

Nature volume 216, pages 272–273 (1967)Cite this article

Abstract

THERE may be at least three modes of mRNA synthesis regulation in cultured mammalian cells: the repression of gene action as postulated in bacteria by Jacob and Monod1; a mechanism in interphase nuclei (G1, S and G2 stages) involving mRNA synthesis only in the uncondensed chromatin and not in the condensed chromatin2,3; and the lack of or, at least, slowing down of mRNA synthesis in M stage cells. Inherent in the last mechanism is the tacit assumption that the overall mRNA synthesis is switched off about the beginning of M stage and on again about the end of the same stage4–13.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Jacob, F., and Monod, A. A., J. Mol. Biol., 31, 318 (1961).

    Article  Google Scholar 

  2. Littau, V. S., Alfrey, V. G., Frenster, J. H., and Mirsky, A. E., Proc. US Nat. Acad. Sci., 52, 93 (1964).

    Article  ADS  CAS  Google Scholar 

  3. Paul, J., and Gilmour, R. S., J. Mol. Biol., 16, 242 (1966).

    Article  CAS  Google Scholar 

  4. Johnson, T. C., and Holland, J. J., J. Cell Biol., 27, 565 (1965).

    Article  CAS  Google Scholar 

  5. Monesi, V., J. Cell Biol., 22, 521 (1964).

    Article  CAS  Google Scholar 

  6. Prescott, D. M., and Bender, M. A., J. Cell Comp. Physiol., 62, 175 (1963).

    Article  CAS  Google Scholar 

  7. Prescott, D. M., and Bender, M. A., Exp. Cell Res., 26, 260 (1962).

    Article  Google Scholar 

  8. Robbins, E., and Scharff, M., in Cell Synchrony (edit. by Cameron, I. L., and Padilla, G. M.), 18, 353 (Academic Press, New York, 1966).

    Book  Google Scholar 

  9. Taylor, J. H., Ann. NY Acad. Sci., 90, 409 (1960).

    Article  ADS  CAS  Google Scholar 

  10. Terasima, T., and Tolmach, L. J., Exp. Cell Res., 30, 344 (1963).

    Article  CAS  Google Scholar 

  11. Crippa, M., Exp. Cell Res., 42, 371 (1966).

    Article  CAS  Google Scholar 

  12. Fernendegen, L. E., and Bond, V. P., Exp. Cell Res., 30, 393 (1963).

    Article  Google Scholar 

  13. Newsome, J., Biochim. Biophys. Acta, 114, 36 (1966).

    Article  CAS  Google Scholar 

  14. Puck, T. T., and Steffen, J., Biophys. J., 3, 359 (1963).

    Article  Google Scholar 

  15. Puck, T. T., Sanders, P., and Petersen, D., Biophys. J., 4, 442 (1964).

    Article  Google Scholar 

  16. Fischer, G. A., and Sartorelli, A. C., Methods Med. Res., 10, 247 (1964).

    CAS  PubMed  Google Scholar 

  17. Doida, Y., and Okada, S., Exp. Cell Res. (in the press).

  18. Watanabe, I., and Okada, S., J. Cell Biol., 32, 309 (1967).

    Article  CAS  Google Scholar 

  19. Buck, C. A., Granger, G. A., and Holland, J. J., Current Mod. Biol., 1, 9 (1967).

    CAS  Google Scholar 

  20. Tobey, R. A., Petersen, D. F., Anderson, E. C., and Puck, T. T., Biophys. J., 6, 567 (1966).

    Article  CAS  Google Scholar 

  21. Tobey, R. A., Anderson, E. C., and Petersen, D. F., Proc. US Nat. Acad. Sci., 56, 1520 (1966).

    Article  ADS  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Division of Experimental Radiology, University of Rochester School of Medicine and Dentistry, Rochester, New York

    Y. DOIDA & S. OKADA

Authors
  1. Y. DOIDA
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. S. OKADA
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

DOIDA, Y., OKADA, S. Determination of Switching-off and Switching-on Time of Overall Nuclear RNA Synthesis. Nature 216, 272–273 (1967). https://doi.org/10.1038/216272a0

Download citation

  • Received:

  • Revised:

  • Issue Date:

  • DOI: https://doi.org/10.1038/216272a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing